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Product Overview
Product Name Topotecan
CAS123948-87-8
FormulaC23H23N3O5
MW421.45
Appearance
Boiling point782.9±60.0 °C | Condition: Press: 760 Torr
PKa8.92±0.40 | Condition: Most Acidic Temp: 25 °C
Product details

WKQ-0001265

中文名称:拓扑替康

中文别称:托泊替康;N-甲苯胺鹽酸鹽;甲胺苯鹽酸鹽;(S)-10-[(二甲氨基)甲基]-4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]中氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮;拓扑替康-d6;2-氮杂二环[2.1.1]己盐酸;(1R)-1-(嘧啶-5-基)乙烷-1-胺盐酸;顺-4-氨基四氢吡喃-3-醇盐酸;拓补替康;帕博西林杂质16盐酸盐

英文名称:Topotecan

英文别名:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-;(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(19S)-8-[(Dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;(S)-Topotecan;10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin;9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin;Evotopin;Hycamptamine;Hycamptin;NSC 609699;Nogitecan;Potactasol;SKF 104864;SKF-S 104864;TopoCED;Topophore C;Topotecan;Topotecan lactone;ZINC 1611274;

分子式:C23H23N3O5

分子量:421.45

CAS号:123948-87-8

纯度:HPLC≥98%

沸点:782.9±60.0 °C | Condition: Press: 760 Torr

密度:1.49±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr

酸系度数:8.92±0.40 | Condition: Most Acidic Temp: 25 °C

储存条件:-20℃,干燥、避光、密封

规格:5mg10mg20mg50mg100mg500mg1g2g等应客户需求包装

供应单位:四川省维克奇生物科技有限公司

供应电话:028-81700200/4008005713

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Related literature
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer
Source:SCI:PHARMACOLOGICAL RESEARCH Author:Yachen Li Notes:影响因子:5.574
Reference description

TPT and DAI, whose structures are shown in Fig. 1, were both purchased from Sichuan Weikeqi Biological Tech (Chengdu, China). Primary antibodies of Bax, Bcl-2, p53, p21, caspase 9, cleaved-caspase 9, ERα, BCRP and GAPDH were all purchased from Protein Tech (Wuhan, China).

Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells
Source:SCI:EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Author:Yongming Bao Notes:影响因子:3.466
Reference description

PFTα (Fig. 1A) (≥98%), Propidium iodide (PI) and Methyl thiazolyl tetrazolium (MTT) were purchased from Sigma-Aldrich (USA). TPT (Fig. 1B) (≥98%) was purchased from Sichuan Weikeqi Biological Tech (Chengdu, China). DNA Topoisomerase I (Topo I), pBR322, Trizol reagent, reverse transcription kit and real-time quantitative kit were purchased from Takara (Dalian, China). Annexin V-EGFP/PI cell apoptosis kit

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